For example, ZCCHC17 is identified as a novel marker for the diagnosis and prognostic assessment of hepatocellular carcinoma (HCC) by regulating the immune cells in the tumor microenvironment (TME) of HCC patients, with specific reference value for immunotherapy of HCC, suggesting that ZCCHCs are associated with immunity [32, 40]. The gene discussed is ZCCHC17; the disease is hepatocellular carcinoma.