The serum FIB level in patients with PC was significantly higher than that in healthy controls, and the FIB level in metastatic PC patients was further increased [28]; compared to patients with low-risk intraductal papillary mucinous neoplasms (IPMN), those with high-risk IPMN had a markedly elevated level of FIB [29]; most PC patients suffered from abnormal coagulation alteration at the time of diagnosis, and tissue factor (TF) and thrombin–antithrombin (TAT) had potential roles in differentiating metastatic PC [30]. This evidence concerns the gene F3 and pancreatic intraductal papillary-mucinous neoplasm.