In contrast, the expression of genes, including STAG3, GATA5, and CACNB2, which are associated with cell proliferation or tumorigenesis, and PRAP1, which is primarily involved in the inhibition of tumor cell apoptosis, increased in mouse KrasG12D/Galc KO pancreatic organoids (Fig. 2a). This evidence concerns the gene PRAP1 and neoplasm.