The indirect effect of SGLT2 inhibition on AF through the concentration of HDL particles (OR 0.89 [95% CI 0.82, 0.97], P = 0.005) had a mediated proportion of 7.59% (95% CI [1.09%, 13.34%], P = 0.011). The gene discussed is SLC5A2; the disease is atrial fibrillation.