The results suggested that RNF43 was negatively correlated with the immune score in COAD (p < 2.2e-16), KIRC (p = 1.4e-14), LIHC (p < 7.8e-12), thymoma (THYM) (p = 4.7e-10) and UVM (p = 0.0021), but was positively correlated with the immune score in DLBC (p = 0.01). This evidence concerns the gene RNF43 and thymoma.