Overall, our findings suggested that RNF43 was associated with OS in UVM, KIRC, and ESCA, associated with DFS in STAD, associated with DSS in KIRC and UVM, associated with PFS in KIRC, UVM, KIRP, and LIHC, confirming the potential role of RNF43 as a promising prognostic biomarker in human cancers. Here, RNF43 is linked to cancer.