To evaluate the potential effects of RNF43 on cancer immunotherapies, the TMB and Immunotherapy cohort in cBioPortal was then employed, and we detected that the RNF43-altered group had a longer OS time than the RNF43-unaltered group (p < 0.001), indicating that RNF43 genomic alternations might improve the immunotherapy efficacy in cancer treatment (Fig. 3H). This evidence concerns the gene RNF43 and cancer.