PGA3 and gastric adenocarcinoma: By single-cell RNA sequencing (scRNA-seq) analysis of primary gastric adenocarcinoma, Zhang et al. have identified 5 cell populations with distinct expression profiles and identified that RNF43 was expressed in a type of well-differentiated gastric adenocarcinoma, GA-FG-CCP which has been reported to be stained positive for PGA3 and MUC6, with the activation of the Wnt/β-catenin signaling pathway in previous studies [25].