RNF43 was highly expressed in rectum adenocarcinoma (READ), and colon adenocarcinoma (COAD), whereas was lowly expressed in lymphoid neoplasm diffuse large B-cell lymphoma (DLBC), glioblastoma (GBM) and sarcoma (SARC) (Fig. 2B). Here, RNF43 is linked to colon adenocarcinoma.