RNF43 was highly expressed in rectum adenocarcinoma (READ), and colon adenocarcinoma (COAD), whereas was lowly expressed in lymphoid neoplasm diffuse large B-cell lymphoma (DLBC), glioblastoma (GBM) and sarcoma (SARC) (Fig. 2B). The gene discussed is RNF43; the disease is diffuse large B-cell lymphoma.