On the contrary, RNF43 was decreased in glioblastoma multiforme (GBM), kidney chromophobe (KICH), kidney renal clear cell carcinoma (KIRC), kidney renal papillary cell carcinoma (KIRP), and pheochromocytoma and paraganglioma (PCPG) compared to the normal tissues (Fig. 2C). This evidence concerns the gene RNF43 and hereditary pheochromocytoma-paraganglioma.