Increased interferon (IFN) signaling, a known driver of pyroptosis, has been described in Still's disease complicated by either macrophage activation syndrome (MAS) or an emergent form of lung disease with hypersensitivity (LD/DHR), but it is unclear whether IFN activation is an active participant or an epiphenomenon. This evidence concerns the gene IFNA1 and systemic-onset juvenile idiopathic arthritis.