RVT comparing the variant distributions of sJIA cases and controls revealed a significant association with rare (MAF<0.01) variants of STXBP2 (p=0.019), and ultra-rare variants of STXBP2 (p=0.006) and UNC13D (p=0.045). The gene discussed is STXBP2; the disease is systemic-onset juvenile idiopathic arthritis.