Neutralizing anti-IFN-α2 Aabs were present in 11 patients (7,7 %) and neutralizing anti-IFN-α2, anti-IFN-β or anti-IFN-ω Aabs in 18 patients (12,6%) with pediatric-onset SLE. The gene discussed is IFNA2; the disease is systemic lupus erythematosus.