S-SpA and SpA had similar frequencies of peripheral arthritis and enthesitis (p>0.05), while tenosynovitis was more frequent (p=0.03) and uveitis less frequent (p=0.002) in S-SpA than SpA. Articular manifestations in S-SpA and SpA patients showed similar therapeutic responses to corticosteroids, cDMARDs and TNFα-inhibitors (p>0.05). Here, TNF is linked to uveitis.