According to whether the hypothalamic-pituitary-gonadal axis (HPGA) occurs or not, precocious puberty is classified as central precocious puberty (CPP) with the HPGA occurring driven by early increased gonadotropin-releasing hormone (GnRH) secretion, which accounts for roughly 80% [4, 5], and as peripheral precocious puberty (PPP) which is independent of GnRH secretion, as well as incomplete precocity, which is the variation of CPP, including premature pubarche (PP), premature adrenarche (PA), premature thelarche (PT) and premature menarche [6–9]. Here, GNRH1 is linked to peripheral precocious puberty.