To date, Fn-carcinoma mechanisms that has been discovered could be summarized as follows: (1) promotion of the Wnt/β-catenin signaling pathway through FadA binding to E-cadherin [12]; (2) cytotoxicity of immune cells such as NK cells and T-cell activity being inhibited [13]; (3) LPS binding to TLR4/MYD88 pathway and mediating downstream NF-κB expression [14]; and (4) the release of Fap2 that binding to Gal-GalNAc ligands [15]. This evidence concerns the gene FN1 and carcinoma.