Hepatocellular carcinoma-derived exosomes can be taken up by paraneoplastic adipocytes to activate five phosphorylated kinases, including AKT, STAT5α, GSK3 α/β, p38α, and ERK1/2 of the NF-κB signaling pathway to promote hepatocellular carcinoma invasion (Wang et al. 2018b). The gene discussed is MAPK3; the disease is hepatocellular carcinoma.