Meanwhile, human plasma exosome Syndecan-1 is a suitable candidate marker for glioma detection (Indira Chandran et al. 2019), exosomal developmental regulatory gene protein (Del-1) to detect early breast cancer (Alix-Panabieres and Pantel 2016), and human plasma exosomal VNN1, CRP, FIBG, IGHA1, and AA1AG1 proteins as candidate markers for the detection of cholangiocarcinoma (Arbelaiz et al. 2017). This evidence concerns the gene VNN1 and central nervous system cancer.