Silva et al. demonstrated that exocytosis in pancreatic ductal adenocarcinoma (PDAC) cells containing MIF (macrophage movement inhibitory factor) induces TGF-P production by liver macrophages, which in turn upregulates hepatic stellate cell fibronectin (FN) expression while recruiting more bone marrow-derived cells and eventually forming pre-metastatic foci in liver sites (Costa-Silva et al. 2015). Here, FN1 is linked to pancreatic ductal adenocarcinoma.