SDC1 and cholangiocarcinoma: Meanwhile, human plasma exosome Syndecan-1 is a suitable candidate marker for glioma detection (Indira Chandran et al. 2019), exosomal developmental regulatory gene protein (Del-1) to detect early breast cancer (Alix-Panabieres and Pantel 2016), and human plasma exosomal VNN1, CRP, FIBG, IGHA1, and AA1AG1 proteins as candidate markers for the detection of cholangiocarcinoma (Arbelaiz et al. 2017).