Interestingly, highly malignant HCC cell-derived exosomes contain high levels of MET proto-oncogenes, receptor tyrosine kinases (MET), S100 calc-binding protein A4 (S100A4), S100A10, S100A11, CAVin 1 (CAV1), and CAV2. The gene discussed is MET; the disease is hepatocellular carcinoma.