We selected the specific inhibitor of FSP1, iFSP1 (MCE, HY-136,057), to interfere with the CoQ-FSP1 pathway to confirm the mechanism of LINC02587,after the intervention of iFSP1(3 μ M; Incubation for 24 h), the level of Ferroptosis of tumor cells increased significantly in two tumor cell lines (LN229 and U87); After si-LINC02587-ii transfection and iFSP1(3 μ M; Incubation for 24 h) intervention, the level of Ferroptosis of tumor cells did not change significantly(Fig. 5F).These findings suggested that in glioma cells, LINC02587 knockdown suppresses the CoQ-FSP1 pathway. Here, AIFM2 is linked to central nervous system cancer.