As shown in Table 1, by stepwise multivariate Cox regression analysis, BNP (HR 1.00 [95% CI 1.00–1.01]), CFS (HR 1.40 [95% CI 1.27–1.54]), and CCI (HR 1.12 [95% CI 1.02–1.22]) emerged as determinants of 6-month mortality risk or re-hospitalization for HF. This evidence concerns the gene NPPB and myalgic encephalomeyelitis/chronic fatigue syndrome.