CXCR2 and colorectal cancer: Interestingly, the authors demonstrated that overexpression of this chemokine enhanced the migration and invasion of colorectal cancer cells by inducing the epithelial-mesenchymal transition (EMT) through activation of the ERK/Elk-1/Snail pathway and the AKT/GSK3β/β-catenin pathway in a CXCR2-dependent manner.