Additionally, ΔNp63 regulates the self-renewal and maintenance of LESCs, which are indispensable for lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC) initiation as well as progression through the regulation of a common landscape of enhancer-associated cell identity genes, such as BCL9L (B-cell CLL/lymphoma 9-like) [201]. The gene discussed is BCL9L; the disease is squamous cell carcinoma.