The main findings of the present study are the following: (1) HBF (post-ischemia and post-heating) and NO plasma concentrations were significantly higher in ATL than in SED, overall denoting a better endothelial function and microcirculatory efficiency; (2) ATL presented a greater plasma antioxidant capacity against both hydroxyl and peroxyl radicals, and increased transcriptional levels of the metabolism regulator PGC-1α; (3) ATL presented higher levels of SIRT1 and miR29, suggested as epigenetic regulators of redox balance and cellular metabolism. The gene discussed is SIRT1; the disease is ischemia.