Through our single-cell atlas of peripheral blood and multi-model analysis approach, our work revealed: (1) single-cell epigenomic and transcriptomic profiles of peripheral blood in BD patients; (2) widespread activation of peripheral autoimmunity profiles in BD patients; (3) putative TF activators that drive the changes chromatin accessibility in BD patients; and (4) potential GRN of BD-associated regulatory interactions within putative TF regulators. Here, TF is linked to Behcet disease.