As observed in the transcriptional data, all the B cell subsets in BD highly expressed interferon-stimulated genes IRF140, IFITM246, and antigen processing and presentation-related molecules HLA-DQB154, and the cytokine IL2RG55, as well as AP-1 family genes JUNB56, MAPK signaling, and NF-kB signaling related genes DUSP138, NFKBIA43 (Fig. 3g, Supplementary Fig. 9c–f, Supplementary Data 7). The gene discussed is FOS; the disease is Behcet disease.