CD28 and Behcet disease: The GO results showed that DN2B in BD patients were enriched in positive regulation of T cell activation, regulation of IL-2 production, activator protein 1 (AP-1) pathway, PD-1 signaling, and costimulation by the CD28 family59, while PB were enriched more in IL-1 signaling FCERI mediated NF-kB activation, Dectin-1 signaling and cellular response to hypoxia (Fig. 3h).