KEGG pathways analysis of both clusters identified 13 overrepresented signaling pathways, including protein processing in the endoplasmic reticulum, TNF signaling pathway, estrogen signaling pathway, NF-κB signaling pathway and several cancer pathways (including acute myeloid leukemia) (Supplementary Table 4). This evidence concerns the gene NFKB1 and acute myeloid leukemia.