Specifically, our epistasis analysis revealed that the alternate ‘G’ allele of SASH1 SNP rs9918382 appears to have a protective effect against AD as it reverses the pathogenic effect of ACTO11 rs7552961 ‘TT’ and APOE rs429358 ‘TC’ genotype combination (Supplementary Fig. S3). The gene discussed is APOE; the disease is Alzheimer disease.