Although SH3BP4 has no established link to AD, a SNP (rs66501349, intergenic to SH3BP4 and CEP19P1) has been marginally associated to poorer cognitive function (χ2-p = 2 × 10–6)26 and its interactor dynamin has strong evidence of a role in AD pathophysiology41, 42. Here, SH3BP4 is linked to Alzheimer disease.