ALB and neoplasm: As shown in Supplementary Fig. 39, the Cy5-BPY@HSA presented better tumor accumulation on the 4T1 orthotopic tumor model than that of Cy5-HSA, which only showed a slight accumulation on MCF-7 xenografted tumor model but exhibited moderate accumulation on the 4T1 orthotopic tumor model (the biodistribution in the body was discussed in Supplementary Note 5).