We identified the cellular source for pro-inflammatory cytokine storm in COVID-19 acute necrotizing encephalopathy patients as primarily originating from three cell subtypes, a CD14+ monocyte subset (Mono_CD14), a proliferative CD8 T subset (CD8_Pro) and a CD4 memory T subset (CD4_Memory) (Fig. 3, Supplementary Fig. 4). Here, CD8A is linked to COVID-19.