CD14 and COVID-19: Unlike the lymphocytes which were depleted in COVD-19 patients with acute necrotizing encephalopathy, most myeloid cell subsets (e.g., Mono_CD14) were increased in peripheral blood (Fig. 2c), consistent with previous results in COVID-19 patients with severe symptoms.9,16 Different myeloid cell subsets exhibited different associations with COVID-19 disease types (Fig. 2b), i.e. megakaryocytes had a significant association with COVID-19-associated acute necrotizing encephalopathy.