IFNA1 and COVID-19: Similar to our observations in B cells, GO terms associated with the IFN response (e.g., type I interferon signaling pathway, response to interferon-α, etc.), especially IFN-I response, were enriched in CD14+ monocytes in COVID-19 acute necrotizing encephalopathy patients relative to healthy controls and other COVID-19 groups (Fig. 6b).