There have been multiple mechanisms hypothesized for COVID-19-related encephalopathy including SARS-CoV-2-associated host response and coagulopathies-related cerebral hypoxic-ischemic injury.8 Recently, many studies have reported that the inflammatory cytokine storm in COVID-19 is triggered by an intense inflammatory response against SARS-CoV-2 virus, which is featured by the overproduction of chemokines (e.g., CCL2, CCL3, CCL5, ect). This evidence concerns the gene CCL2 and Encephalopathy.