NEFL and amyotrophic lateral sclerosis: Aggregation of wild-type (WT) NF-L and other NF proteins is also a pathological hallmark of a variety of neurological conditions, including Alzheimer’s disease (AD)22, Parkinson’s disease (PD)23, amyotrophic lateral sclerosis (ALS)24, giant axonal neuropathy (GAN)16, and spinal muscular atrophy25.