DKK3 and breast cancer: Interestingly, Dkk3 was inversely correlated with genes indicative of an antitumor immune response (e.g., Cd4, Cd8a, Gzma, Gzmb, and Ifng) in Basal BC across data sets, a pattern not observed with family member Dkk1 or Dkk2 (Figure 7C and Supplemental Table 2).