In our work, we show that overexpression of NDRG1 with metixene beyond the baseline elevated levels in triple-negative breast cancer cell lines and brain metastases, such as MDA-MB-231Br, induced incomplete autophagy, leading to decreased cell viability in vitro and improvement of survival in multiple preclinical models in vivo. The gene discussed is NDRG1; the disease is triple-negative breast carcinoma.