At the molecular level, the NP–/– AML transcriptome was predominantly regulated by p53 loss, whereas the NPmut AML transcriptome was driven by the synergistic interaction between mutant p53 and oncogenic NRAS signaling (Figure 3B) and had minimal overlap with the NP–/– AML transcriptome (Figure 3D). This evidence concerns the gene TP53 and acute myeloid leukemia.