SNORD118 and Leukoencephalopathy: Leukoencephalopathy with calcifications and cysts (LCC; also known as Labrune syndrome, OMIM #614,561) is a rare, autosomal recessive disorder caused by biallelic mutations in small nucleolar RNA, C/D Box 118 (SNORD118), a non-protein-coding, small nucleolar RNA gene on chromosome 17p13 [131, 132].