Microtubule stability is known to be related to the regulation of EMT, and knockdown of human tubulin β-IVa (TUBB4A) reduces GSK3β ubiquitination and degradation, increasing the expression of E-cadherin in PCa cells, while the expression of N-cadherin and vimentin decrease [39]. The gene discussed is TUBB4A; the disease is posterior cortical atrophy.