In PCa, the function of CUL4B E3 Ub ligase, through its transcriptional repressive activity, leads to the trimethylation of miR200b/c, in turn inhibiting its transcription and promoting BMI1-regulated PCa stem cell traits that lead to PCa progression and metastasis (Fig. 5a) [67]. Here, CUL4B is linked to posterior cortical atrophy.