This review will briefly describe the ubiquitination process and E3 ubiquitin ligase, it also focuses on the recently discovered ubiquitination through the effects of epithelial-mesenchymal transition (EMT), AR, cancer stem cells (CSCs), energy metabolism, cell cycle, and other mechanisms lead to the occurrence and transfer of PCa; in the last part of the article, we briefly summarize the current treatment methods for PCa by E3 ubiquitin ligase. Here, AR is linked to posterior cortical atrophy.