CD8A and colonic neoplasm: Recently, Vasaikar reported a negative correlation between glycolytic activity and infiltration of CD8 + T cells in MSI-H colon cancer, while Lu’s team demonstrated that deficiency of the cGAS-STING pathway in MMRd tumors dramatically diminishes CD8 + T-cell infiltration, suggesting probable underlying mechanisms to facilitate tumorigenesis with high mutational burden [17, 20].