Figure 1B illustrates that PD-L1 levels are also high in RKO and SW480 colon cancer cells and knockdown of NR4A1 (Fig. 1B), PD-L1 (Fig. 1C), Sp1 (Fig. 1D) or treatment with mithramycin (Fig. 1E) or CDIM/NR4A1 antagonists (Fig. 1F) decreased PD-L1 levels these cells. The gene discussed is SP1; the disease is colonic neoplasm.