The results of studies in RKO, SW480 and MC-38 colon cancer cells show that knockdown of NR4A1 or treatment with DIM-3,5-Cl2 and DIM-3-Br-5-OCF3 decreases PD-L1 expression (Figs. 1, 2, 3). Here, NR4A1 is linked to malignant colon neoplasm.