The methylation data of the NF-κB gene set obtained in pancancer through the GSCALite platform showed that the level of NF-κB gene methylation in a variety of cancers differed from that of normal samples, and the expression of MYD88, TNFRSF1A, TNFRSF1B, MAP3K14, and other genes had a strong correlation with the level of methylation, and all affected the survival of cancer patients, and the results were statistically different (Figure 2A). The gene discussed is TNFRSF1A; the disease is cancer.