NFKB1 and neoplasm: In order to confirm the role of commonly used tumor-targeted therapy drugs in the treatment of KIRC, we conducted GDSC analysis, and the results showed that the IC50 of most targeted drugs for KIRC treatment is related to the level of gene expression in the NF-κB pathway, which indicates that the selection of different drugs according to the characteristics of patients can achieve better efficacy or appropriately reduce drug concentrations to reduce the side-effects of drugs.