NFKB1 and Familial prostate cancer: For example, NF-κB is involved in the proliferation of the breast cancer cell line, T47D, by regulating cyclin D1 and inducing the upregulation of matrix metalloproteases (MMP) 2 and 9; metastasis of liver cancer cell lines, QGY-8024 and PLC97, was increased; and activation of the expression of VEGF, MMP9, and interleukin (IL)-8 in the human prostate cancer cell line, PC-3M, leading to the formation of new blood vessels and invasion of cancer cells.