In the mRNA expression profile, we can observe the expression level of NF-κB-related genes in various cancer types; particularly in patients with KIRC, TRADD, MYD88, TNFRSF1A, TNFRSF1B, MAP3K14, TNFAIP3, and NFKBIA were higher in KIRC tissues than in normal tissues, and the expression of IL1A, MAP3K1, CHUK, and IL1R1 were lower in the KIRC tissues than in normal tissues. This evidence concerns the gene MAP3K1 and cancer.