NFKB1 and neoplasm: Here, we first explored the relationship between the NF-κB pathway and expression of various classical protooncogenes, for example, the low-expression of BRAF, PTEN, KRAS, MTOR, and PIK3CA in the NF-κB downregulation group (C3), indicating that the interruption of the NF-κB pathway is related to tumor promotion.