In addition, acetylation and deacetylation of transcription factors have also been shown to be associated with a variety of kidney diseases, including diabetic nephropathy [22, 23], the analysis of histone acetylation-related genes showed that abnormal expression of SIRT and HDACs also had a strong correlation with abnormalities in the NF-κB pathway, the expression of HDACs in the NF-κB downregulated group (C3) was slightly lower than that in the other two groups (Figure 4C). Here, NFKB1 is linked to diabetic kidney disease.