PGAM1 and nonpapillary renal cell carcinoma: Upon scrutinizing the expression of PGAM1 across diverse sample types, cancer stages, metastasis stages, and ccRCC subtypes in The Cancer Genome Atlas (TCGA) (Figure 2B–2E), we observed that PGAM1 expression was significantly amplified in the first stage of metastatic KIRC, and both subtypes of ccRCC exhibited an upward trend.