Interestingly, mRNA levels for CNOT1, 2, and 3 increased by a maximum of twofold compared to uninfected cells during infections (Fig 4B), suggestive of a translational modality to CNOT1 and CNOT3 protein upregulation, a feature previously reported for the regulation of CNOT3 expression in response to diet (Morita et al, 2011). Here, CNOT1 is linked to infection.