Fibroblast growth factor receptors (FGFRs) comprising FGFR1,FGFR2,FGFR3 and FGFR4 have been reported to play important roles in the regulation of the main target genes of lenvatinib and control tumour metabolism in many cancer types including HCC.5 This evidence concerns the gene FGFR4 and hepatocellular carcinoma.