The same result was also found in HCC cell lines that says that MHCC‐97H and Hep 3B cells with relative high expression of KDM6A showed lower IC50 of lenvatinib compared to SNU 449 and PLC/PRF/5 with relative low expression of KDM6A (Supporting Information Figure S7E). This evidence concerns the gene KDM6A and hepatocellular carcinoma.