GLI1 and esophageal squamous cell carcinoma: Additionally, through the IHC analysis of clinical ESCC samples, the expression of Gli1 and pGli1 Ser112/Thr115/Ser116 was positively correlated with stromal CCL22, indicating that the above ESCC cases possibly experience canonical HH pathway as well as CCL22‐regulated Gli1 activation independent of SMO.