Interestingly, glioma‐associated oncogene 1 (Gli1) can be activated by phosphatidylinositol 3 kinase (PI3K)/AKT pathway in mesenchymal stromal cells,23 critical for immune response in macrophages regulated by Foxo1/β‐catenin axis,24 and stimulated by mammalian target of rapamycin (mTOR)/ribosomal protein S6 kinase 1 (S6K1) signaling cascade in chondrosarcoma.25 The gene discussed is MTOR; the disease is chondrosarcoma.