Our previous work has shown that tumor‐associated macrophages (TAMs)‐released C‐C motif chemokine 22 (CCL22) stimulates the activity of its receptor‐C‐C chemokine receptor type 4 (CCR4) in ESCC cells and subsequently activates the intratumoral focal adhesion kinase (FAK)/AKT axis to induce the malignant progression of ESCC.14 This evidence concerns the gene PTK2 and esophageal squamous cell carcinoma.