Some studies have shown that the expression of Circ-HECW2 can regulate miR-93 methylation, and then affect the growth and development (Zuo et al., 2021), and studies by Krumm et al. (2015) have shown that there is a link between mutations in the HECW2 gene and the occurrence of autism. The gene discussed is HECW2; the disease is autism.