PTEN and neoplasm: Specifically, the mean H-score for PTEN immunoreactivity in melanoma tumor samples with tumor thickness less than or equal to 2.0 mm (T1+T2) was 0.95, while the mean H-score for PTEN immunoreactivity was 0.57 in melanoma tumor samples with tumor thickness greater than 2.0 mm (T3+T4) (Figure 2).