IL6 and Miyoshi myopathy: In addition to inducing apoptosis in MM cells, inhibiting the release of bone marrow-derived growth factors like transforming growth factor and insulin-like growth factor into the marrow, downregulating the production of interleukin 6 (IL-6) from the bone marrow stroma, and stimulating T-cell-mediated antiplasma cell activity in the marrow, BPs may also have antimyeloma effects [12].