miRNA‐195 overexpression observed in type 1 (T1DM) and type 2 (T2DM) diabetes mellitus hearts may lead to down‐regulation of sirtuin 1 (SIRT1), and impaired SIRT1 activity may affect oxidative metabolism, mitochondrial function and increase ROS production (Zheng et al., 2015). This evidence concerns the gene SIRT1 and diabetes mellitus.