In addition, Jin et al.’s (2022) latest study identified fibroblast growth factor 21 (FGF21)–sirtuin 3 (SIRT3) as a novel molecular sensor of exercise, which can promote mitochondrial integrity and stability of cardiac function in the diabetic myocardium, The expression of mitochondrial SIRT3 induced by FGF21 is a key intermediary to prevent DCM through exercise. This evidence concerns the gene FGF21 and familial dilated cardiomyopathy.