The most significantly enriched KEGG pathways of these DE-lncRNAs between RA and OA were associated with the T cell receptor signalling, NF − kappa B signalling, chemokine signalling, FoxO signalling, and B cell receptor signalling pathways, as well as osteoclast differentiation (Fig. 2B). The gene discussed is TBXT; the disease is rheumatoid arthritis.