To verify the results of lncRNA and mRNA sequencing, we used qRT-PCR to detect the expression of three lncRNAs (MIR3945HG-202, NONHSAT193357.1, and NONHSAT190641.1) and three mRNAs (CCL5, PFKP, and MPIG6B) selected from serum exosomes in an independent validation cohort of patients with RA, healthy controls, and patients with OA. The gene discussed is CCL5; the disease is rheumatoid arthritis.