Recent evidence has also shown that the lncRNA NEAT1 derived from PBMC exosomes contributes to RA development via the miR-23a/MDM2/SIRT6 axis [18] and that serum-derived exosomes containing NEAT1 may promote RA occurrence by regulating the miR-144-3p/ROCK2 axis [19]. The gene discussed is SIRT6; the disease is rheumatoid arthritis.