Several markers of inflammation, tissue injury and organ dysfunction, mainly of cardiac and renal tissues were altered in both groups due to the severity of infection (Additional file 1: Table S2–S4,S6–S7), but more intensely in DM group (Table 2), presenting higher levels of CRP, LDH, troponin, PKC, lactate and BNP. This evidence concerns the gene NPPB and diabetes mellitus.