INS and obesity due to melanocortin 4 receptor deficiency: Comorbidities conditioning higher risk for severity of COVID-19 (hypertension, diabetes, cardiovascular disease and obesity), associated with insulin resistance, oxidative stress and vascular damage caused by low-grade inflammation that permeate all these comorbidities usually present worldwide were exacerbated by sedentary lifestyle, inadequate nutrition and the stress of modern life, worsened by the lockdown [1–8].