This sexual dimorphism had been attributed to gender difference in immune response, higher expression of transmembrane serine protease 2 (TMPRSS2) promoted by androgen, facilitating SARS-COV-2 entry [19], frequent prevalence of comorbidities (hypertension, CVD, chronic lung diseases), occupational exposure, risk behaviors (smoking and alcohol), worse health habits and irregular medical appointments [20, 21]. This evidence concerns the gene TMPRSS2 and chronic lung disease.