Zophobas morio (Z. morio) hemolymph can decrease the levels of NLRP3, caspase-1 and NLRP6 and inhibit the secretion of IL-1β and IL-18, thereby attenuating E. coli- or Staphylococcus simulans (S. simulans)-induced pyroptosis; thus, it can be a new therapeutic candidate for bovine mastitis [37]. The gene discussed is IL18; the disease is Bovine mastitis.