SMAD4 and cervical carcinoma: Mechanistically, we found that 1) CSRP2BP promoted cervical cancer EMT and metastasis by upregulating N-cadherin, and 2) CSRP2BP increased N-cadherin expression by acetylating H4K5 and H4K12 in the promotor region of N-cadherin through cooperation with Smad4 (Fig. 7I).