TGFB1 and liver dysplastic nodule: Sirtuin1 (Sirt1) is a nicotinamide adenine dinucleotide-dependent deacetylase that targets NF-κB, p53, TGF-β1, and p66Shc, among others, to exert its anti-inflammatory, anti-apoptotic, and anti-fibrotic effects; it also protects mitochondrial functions in DN [138].