This is consistent with what Smith TA et al. reported in children and adolescents with type-1 diabetes: an extra 40% of the insulin dose for CSII insulin and an additional 25% bolus for MDI insulin for a high-fat, high-protein (HFHP) breakfast optimizes postprandial glycemia without a statistically significant increase in hypoglycemia [15, 16]. This evidence concerns the gene INS and type 1 diabetes mellitus.