However, no effect on renal transport and activation of the WNK-NCC pathway was observed in SM22-Cul3Δ9 mice in contrast to mice ubiquitously expressing Cul3Δ9 (pgk-Cul3Δ9), which showed both electrolyte imbalance and hypertension [56]. The gene discussed is SLC12A3; the disease is hypertensive disorder.