CUL3 and Abnormality of metabolism/homeostasis: Variants in CUL3 are often associated with growth impairment in addition to hypertension and electrolyte imbalances and are commonly manifested in infants and children [14, 18–21], while variants in KLHL3 and WNKs are associated with hypertension and electrolyte imbalances in mostly adult FHHt patients [14–16].