IL-10 secreted by M2 macrophages is a potent anti-inflammatory cytokine with the ability to suppress synthesis of proinflammatory cytokines and chemokines in macrophages through activation of STAT3 signaling [69] and improves cardiac remodeling after myocardial infarction by stimulating M2 macrophage polarization and fibroblast activation [70, 71]. The gene discussed is IL10; the disease is myocardial infarction.