PTEN and cancer: Subtype analysis showed that B/My MPAL blast-specific genes included AUTS2, MEF2A, RB1CC1, and HBEGF, whereas T/My MPAL blasts overexpressed PTEN, ESYT2, KMT2C, and PTGG1IP. Heparin-binding epidermal growth factor-like growth factor (HBEGF) has been implicated in several cancers including leukemias as an inducer of tumor growth [65–67], and has previously been targeted in various cancers with small molecule inhibitors [67–69].