NR3C1 and colorectal cancer: This included activation of protein kinase C (PKC) via G-Protein coupled receptor, gastrin signaling in inflammatory response, angiotensin II receptor type 1 (AGTR1) signaling via p38, extracellular-signal-regulated kinase (ERK) and epidermal growth factor receptor (EGFR) signaling, and glucocorticoid receptor signaling, as well the role of IL8 typically seen in colorectal cancer (Fig. 2F).