Comparison of T/My MPAL single-cell profiles with ETP and non-ETP T-ALL cases showed greater overlap of T/My MPAL with ETP-ALL as one may expect; however, certain T/My MPAL samples had distinct non-overlapping clusters with greater myeloid antigen expression (LYZ, CD74) confirming this indeed is a separate entity. Here, LYZ is linked to acute lymphoblastic leukemia.