This included activation of protein kinase C (PKC) via G-Protein coupled receptor, gastrin signaling in inflammatory response, angiotensin II receptor type 1 (AGTR1) signaling via p38, extracellular-signal-regulated kinase (ERK) and epidermal growth factor receptor (EGFR) signaling, and glucocorticoid receptor signaling, as well the role of IL8 typically seen in colorectal cancer (Fig. 2F). This evidence concerns the gene CXCL8 and colorectal cancer.