Specific genes that were overexpressed in the blasts of both MPAL subtypes compared to other acute leukemias included CD81 and LMO2. CD81, which is a member of transmembrane 4 superfamily, has been associated with a poor prognosis in AML [59] and is also a known marker in B-ALL [60, 61]. Here, CD81 is linked to mixed phenotype acute leukemia.