In the present work, further results showed that (Fig. 6B, C) hsa-circ-0004771 in the exosomes of cell culture media participated in 5-FU resistance by targeting miR-653/ZEB2 pathway in CRC, and there was a clear additive (suppressive) effect between hsa-circ-0004471 and miR-653 mimic. The gene discussed is ZEB2; the disease is colorectal carcinoma.