HSPA8 and systemic lupus erythematosus: In our other paper on SLE [18], we found that co-modification of lysine crotonylation (Kcr) and Khib occurring in HSPA8, a key protein in the Antigen processing and presentation pathway, may increase ATP hydrolysis and promote antigen binding to MHC II molecules, which may be associated with the pathogenesis of SLE.