CCND1 and cancer: These results are in alignment with Tian et al., 2017 where they found that the activation of the p15/cyclin D1 pathway greatly promotes NSCLC carcinogenesis [37], another supportive study showed that the anti-proliferative effect of betulinic acid treatment on various cancer cell lines via decreasing the expression levels of Bcl-2, cyclin D1 genes [38].