Multivariate COX analysis of 44 apoptosis-related genes found that 12 apoptosis-related genes were significantly associated with the prognosis of bladder cancer patients, namel ABCB9, SPTBN2, GULP1, OAS1, ANXA6, IGF1, P4HB, RAD9A, DNASE2B, NES, FANCF and DPYSL2. The gene discussed is ANXA6; the disease is urinary bladder cancer.