Multivariate COX analysis of 44 apoptosis-related genes found that 12 apoptosis-related genes were significantly associated with the prognosis of bladder cancer patients, namel ABCB9, SPTBN2, GULP1, OAS1, ANXA6, IGF1, P4HB, RAD9A, DNASE2B, NES, FANCF and DPYSL2. This evidence concerns the gene IGF1 and urinary bladder cancer.