For example, Chang et al. demonstrated that baseline CRP could serve as a discrimination biomarker for MDD and bipolar II disorder in drug naïve patients (cutoff value: 621.6 ng/mL; AUC value: 0.816), and patients with baseline CRP greater than 621.6 ng/mL had 28.2 higher odds of bipolar II disorder [37]. This evidence concerns the gene CRP and major depressive disorder.